منابع مشابه
Neuron Migration: Anillin Protects Leading Edge Actin
Establishment of a neuronal system requires proper regulation of the F-actin-rich leading edges of migrating neurons and neurite growth cones. A new study shows that RhoG signals through the multi-domain protein anillin to stabilize F-actin in these structures.
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Repulsive guidance cues can either collapse the whole growth cone to arrest neurite outgrowth or cause asymmetric collapse leading to growth cone turning. How signals from repulsive cues are translated by growth cones into this morphological change through rearranging the cytoskeleton is unclear. We examined three factors that are able to induce the collapse of extending Helisoma growth cones i...
متن کاملSpatial regulation of actin dynamics: a tropomyosin-free, actin-rich compartment at the leading edge.
Rapid polymerization of a network of short, branched actin filaments takes place at the leading edge of migrating cells, a compartment enriched in activators of actin polymerization such as the Arp2/3 complex and cofilin. Actin filaments elsewhere in the cell are long and unbranched. Results reported here show that the presence or absence of tropomyosin in these different actin-containing regio...
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During CNS development, oligodendrocytes wrap their plasma membrane around axons to generate multilamellar myelin sheaths. To drive growth at the leading edge of myelin at the interface with the axon, mechanical forces are necessary, but the underlying mechanisms are not known. Using an interdisciplinary approach that combines morphological, genetic, and biophysical analyses, we identified a ke...
متن کاملLeading Edge Vortices
Leading-edge vortices that form at offdesign conditions can profoundly influence the aerodynamic characteristics of highly swept slender wings. predict wing geometry effects on the progressive spanwise development of leading-edge vortices is presented. This method, which can account for sweep, camber, twist, airfoil shape, flap deflections, and planform shape, is shown to be a useful tool for a...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2008
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.1805rr4